Glucocorticoid Receptor

Related Products

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor Related Products (350)
Antibodies (4)

By Effects:	Controls (9) Ligands (6) Inhibitors (18) Agonists (183) Antagonists (20) Activators (14) Modulators (32)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-113854

AZD2906	Agonist	99.90%
AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC₅₀s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively.

HY-14234

Glucocorticoid receptor agonist	Agonist	99.06%
Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC₅₀ values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin.

HY-B0603

Fluticasone	Agonist	98.70%
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC₅₀ value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells.

HY-17570

Desoximetasone		99.31%
Desoximetasone is a corticosteroid and a substrate of cytochrome P450 3A4. Desoximetasone has anti-inflammatory, anti-allergic, and immunosuppressive effects. Desoximetasone can be used in the research of various skin diseases, such as skin allergies, atopic dermatitis, and psoriasis.

HY-B0727

Betamethasone valerate	Agonist	99.81%
Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (³H dexamethasone) to human epidermis and mouse skin with IC₅₀s of 5 and 6 nM, respectively.

HY-B0629

Mometasone		99.13%
Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis.

HY-B1618R

Corticosterone (Standard)	Agonist
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.

HY-103662

GW-870086	Agonist	99.59%
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC₅₀ of 10.1 in A549 cells expressing NF-κB.

HY-B1616

Clobetasone butyrate	Agonist	99.80%
Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.

HY-148435

Glucocorticoid receptor agonist-2	Agonist	99.65%
Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC₅₀ value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373.

HY-16718

Dagrocorat	Agonist	99.90%
Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC₅₀=1.3 μM in human liver microsomes) and CYP2D6 (K_i=0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis.

HY-13570C

Betamethasone disodium phosphate		99.84%
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids.

HY-112710

ORIC-101	Antagonist	99.30%
ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC₅₀ of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14648G

Dexamethasone (GMP)	Agonist
Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor.

HY-106673

Hydrocortisone buteprate		99.29%
Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. Hydrocortisone buteprate (Hydrocortisone probutate) is available as a 0.1% cream or ointment formulation.

HY-B0636S3

Triamcinolone acetonide-d₆	Agonist	99.12%
Triamcinolone acetonide-d₆ is deuterium labeled Triamcinolone acetonide.

HY-B1087

Prednisolone hemisuccinate		99.89%
Prednisolone hemisuccinate is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions.

HY-B1829AR

Dexamethasone phosphate disodium (Standard)	Agonist
Dexamethasone phosphate (disodium) (Standard) is the analytical standard of Dexamethasone phosphate (disodium). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is an orally active Glucocorticoid receptor agonist.

HY-17461S1

Cortisone-d₈	Agonist	98.17%
Cortisone-d₈ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.

HY-145351

BAY 1003803	Agonist	99.85%
BAY 1003803 is a glucocorticoid receptor agonist for the topical research of psoriasis or severe atopic dermatitis.

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Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor Related Products (350)

Antibodies (4)

Glucocorticoid Receptor Related Products (350):